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Chmura, Steven
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overview Dr. Steven J. Chmura is an Associate Professor in the Department of Radiation and Cellular Oncology and Director of Clinical and Translational Research at The University of Chicago. Steven J. Chmura MD, PhD is the director of Clinical and Translational Research for Radiation Oncology at the University of Chicago for over a decade. He has been actively involved in both the clinical implementation of stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT) and related translational and clinical research, as well as the integration of SRS and SBRT into other systemic therapies. His clinical interests include breast cancer, limited metastatic disease, immunotherapy, and technologic improvements in the delivery of radiotherapy. Dr. Chmura is a leader in the NCI cooperative groups. His work has led to the first international oligmetastatic trials through NRG Oncology examining the safety of treating lung and breast cancer patients as a Phase II/III trial examining potential improvements to progression-free survival and overall survival. Dr. Chmura's work in radio-immunology has also translated into multiple investigator-sponsored trials along with the now accruing NCI-sponsored (A091605) trial randomizing the role of SBRT combined with pembrolizumab in advanced Merkel cell carcinoma; such integration of ablative radiotherapy and immunotherapy along with advancing the search for biomarkers is currently Dr. Chmura's focus.
One or more keywords matched the following items that are connected to Chmura, Steven
Item TypeName
Concept Dose-Response Relationship, Radiation
Concept Patient Acceptance of Health Care
Concept Radiation Injuries
Concept Radiation-Sensitizing Agents
Concept Radiation Dosage
Concept Radiation Tolerance
Concept Radiation Pneumonitis
Concept Radiation Oncology
Concept Patient Care Management
Concept Patient Positioning
Concept Patient Selection
Concept Radiation, Ionizing
Academic Article Loss of ceramide production confers resistance to radiation-induced apoptosis.
Academic Article Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation.
Academic Article Radiogenetic therapy: on the interaction of viral therapy and ionizing radiation for improving local control of tumors.
Academic Article Strategies for enhancing viral-based gene therapy using ionizing radiation.
Academic Article Down-regulation of ceramide production abrogates ionizing radiation-induced cytochrome c release and apoptosis.
Academic Article Prospects for viral-based strategies enhancing the anti-tumor effects of ionizing radiation.
Academic Article Intensity-modulated radiation therapy in advanced head and neck patients treated with intensive chemoradiotherapy: preliminary experience and future directions.
Academic Article Association between bone marrow dosimetric parameters and acute hematologic toxicity in anal cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy.
Academic Article Intensity-modulated radiotherapy in treatment of pancreatic and bile duct malignancies: toxicity and clinical outcome.
Academic Article Does the number of lymph nodes examined in patients with lymph node-negative breast carcinoma have prognostic significance?
Academic Article An initial report of a radiation dose-escalation trial in patients with one to five sites of metastatic disease.
Academic Article Intensity-modulated radiation therapy (IMRT) in the treatment of anal cancer: toxicity and clinical outcome.
Academic Article Calculation and prediction of the effect of respiratory motion on whole breast radiation therapy dose distributions.
Academic Article A multi-institutional acute gastrointestinal toxicity analysis of anal cancer patients treated with concurrent intensity-modulated radiation therapy (IMRT) and chemotherapy.
Academic Article Optimization of the temporal pattern of radiation: an IMRT based study.
Academic Article Validation of temporal optimization effects for a single fraction of radiation in vitro.
Academic Article Concurrent chemotherapy and intensity-modulated radiation therapy for anal canal cancer patients: a multicenter experience.
Academic Article Magnetic resonance imaging identifies multifocal and multicentric disease in breast cancer patients who are eligible for partial breast irradiation.
Academic Article Stereotactic body radiotherapy for multisite extracranial oligometastases: final report of a dose escalation trial in patients with 1 to 5 sites of metastatic disease.
Academic Article Hypofractionated image-guided radiation therapy for patients with limited volume metastatic non-small cell lung cancer.
Academic Article Feasibility and acute toxicity of hypofractionated radiation in large-breasted patients.
Academic Article gamma-H2AX as a therapeutic target for improving the efficacy of radiation therapy.
Academic Article Intensity-modulated radiation therapy in the treatment of gastric cancer: early clinical outcome and dosimetric comparison with conventional techniques.
Academic Article Outcomes in black patients with early breast cancer treated with breast conservation therapy.
Academic Article Radiation oncology fourth-year medical student clerkships: a targeted needs assessment.
Academic Article Radiation-induced equilibrium is a balance between tumor cell proliferation and T cell-mediated killing.
Academic Article Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs.
Academic Article The utility of FDG-PET for assessing outcomes in oligometastatic cancer patients treated with stereotactic body radiotherapy: a cohort study.
Academic Article An analysis of radiation necrosis of the central nervous system treated with bevacizumab.
Academic Article Radiation oncology medical student clerkship: implementation and evaluation of a bi-institutional pilot curriculum.
Academic Article A national radiation oncology medical student clerkship survey: didactic curricular components increase confidence in clinical competency.
Academic Article Assessment of interfractional variation of the breast surface following conventional patient positioning for whole-breast radiotherapy.
Academic Article An image-guided study of setup reproducibility of postmastectomy breast cancer patients treated with inverse-planned intensity modulated radiation therapy.
Academic Article Medical Student Perspectives on a Multi-institutional Clerkship Curriculum: A Report From the Radiation Oncology Education Collaborative Study Group.
Academic Article Risk of second malignancies in patients with early-stage classical Hodgkin's lymphoma treated in a modern era.
Academic Article Feasibility and toxicity of hypofractionated image guided radiation therapy for large volume limited metastatic disease.
Academic Article Stereotactic radiotherapy for pulmonary metastases.
Academic Article Hypofractionated radiotherapy does not increase acute toxicity in large-breasted women: results from a prospectively collected series.
Academic Article Taking "the Game" Out of The Match: A Simple Proposal.
Academic Article The evolving role of radiotherapy in treatment of oligometastatic NSCLC.
Academic Article Benchmark Credentialing Results for NRG-BR001: The First National Cancer Institute-Sponsored Trial of Stereotactic Body Radiation Therapy for Multiple Metastases.
Academic Article Promoting the Appropriate Use of Advanced Radiation Technologies in Oncology: Summary of a National Cancer Policy Forum Workshop.
Academic Article Educational Impact of a Structured Radiation Oncology Clerkship Curriculum: An Interinstitutional Comparison.
Academic Article Definitive Stereotactic Body Radiotherapy (SBRT) for Extracranial Oligometastases: An International Survey of >1000 Radiation Oncologists.
Academic Article Utilization trend and regimens of hypofractionated whole breast radiation therapy in the United States.
Academic Article A feasibility study of 2-mm bolus for postmastectomy radiation therapy.
Academic Article Structured Radiation Oncology Clerkship Curricula: Evaluating the Effect on Residency Applicant Knowledge of Radiation Oncology.
Academic Article American Association of Physicists in Medicine Task Group 263: Standardizing Nomenclatures in Radiation Oncology.
Academic Article Response to BRAF/MEK Inhibition After Progression With BRAF Inhibition in a Patient With Anaplastic Pleomorphic Xanthoastrocytoma.
Academic Article Classification for long-term survival in oligometastatic patients treated with ablative radiotherapy: A multi-institutional pooled analysis.
Academic Article Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors.
Academic Article The Evolution of Radiation Therapy in Metastatic Breast Cancer: From Local Therapy to Systemic Agent.
Academic Article Management of glioblastoma in elderly patients.
Academic Article National Radiation Oncology Medical Student Clerkship Trends From 2013 to 2018.
Academic Article Elevated Radiation Therapy Toxicity in the Setting of Germline PTEN Mutation.
Academic Article Tumor-reprogrammed resident T cells resist radiation to control tumors.
Academic Article Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001.
Academic Article NRG/RTOG 1122: A phase 2, double-blinded, placebo-controlled study of bevacizumab with and without trebananib in patients with recurrent glioblastoma or gliosarcoma.
Academic Article Alternative Multidisciplinary Management Options for Locally Advanced NSCLC During the Coronavirus Disease 2019 Global Pandemic.
Academic Article Clinical and Radiographic Presentations of COVID-19 Among Patients Receiving Radiation Therapy for Thoracic Malignancies.
Academic Article Coronavirus Disease 2019 Infection Prevention and Control Practices in Wuhan Radiation Therapy.
Academic Article Cytoreduction and the Optimization Of Immune Checkpoint Inhibition with Radiation Therapy.
Academic Article Suppression of local type I interferon by gut microbiota-derived butyrate impairs antitumor effects of ionizing radiation.
Academic Article Radiation treatment planning study to investigate feasibility of delivering Immunotherapy in Combination with Ablative Radiosurgery to Ultra-High DoSes (ICARUS).
Academic Article Evaluation of Safety of Stereotactic Body Radiotherapy for the Treatment of Patients With Multiple Metastases: Findings From the NRG-BR001 Phase 1 Trial.
Academic Article A Phase 1 Trial of Concurrent or Sequential Ipilimumab, Nivolumab, and Stereotactic Body Radiotherapy in Patients With Stage IV NSCLC Study.
Academic Article Evaluation of Dose Distribution to Organs-at-Risk in a Prospective Phase 1 Trial of Pembrolizumab and Multisite Stereotactic Body Radiation Therapy (SBRT).
Academic Article Stereotactic Body Radiation Therapy and Immunotherapy in Abdominal and Pelvic Lymph Node Metastases.
Academic Article Evaluation of Initial Metastatic Tumor Location and Radiation Response to Determine Outcomes in Patients Who Received Combination Stereotactic Body Radiotherapy and Immunotherapy for NSCLC.
Academic Article A multi-center prospective study of re-irradiation with bevacizumab and temozolomide in patients with bevacizumab refractory recurrent high-grade gliomas.
Academic Article Should We Target Oligometastatic EGFR-Mutated Non-Small Cell Lung Cancer With Radiotherapy Before Administering Targeted Systemic Therapy?
Academic Article Oligometastatic Breast Cancer.
Academic Article Predictors of Pneumonitis in Combined Thoracic Stereotactic Body Radiation Therapy and Immunotherapy.
Academic Article Stereotactic Body Radiation Therapy for Oligometastasis: GUst Do It?
Academic Article Highly aneuploid non-small cell lung cancer shows enhanced responsiveness to concurrent radiation and immune checkpoint blockade.
Concept Radiation Oncologists
Grant NCI National Clinical Trials Network-Network Lead Academic Participating Sites
Academic Article Radiation dose, schedule, and novel systemic targets for radio-immunotherapy combinations.
Academic Article Combined Stereotactic Body Radiation Therapy and Immune Checkpoint Inhibition for Liver Metastases: Safety and Outcomes in a Pooled Analysis of 3 Phase 1 Trials.
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  • radiation
  • safety